Cellular Therapy & Hematology Resources

Thorvardur R. Halfdanarson, MD; William J. Hogan, MBBCh; and Bo E. Madsen, MD, MPH have published and excellent article titled “Emergencies in Hematology and Oncology”. The following is the Outline from the article (clicking each link will take you to the article on their website):

1. Metabolic Emergencies
   1. Hypercalcemia of Malignancy
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
   2. Tumor Lysis Syndrome
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Risk Stratification
      4. Prevention and Treatment
   3. Lactic Acidosis
   4. Hyponatremia
   5. Hypoglycemia
   6. Adrenal Insufficiency
2. Hematologic Emergencies
   1. Hyperviscosity Due to Monoclonal Proteins
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
   2. Hyperleukocytosis and Leukostasis
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
3. Neurologic Emergencies
   1. Malignant Spinal Cord Compression
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
   2. Brain Metastases
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
4. Cardiovascular Emergencies
   1. Malignant Pericardial Effusion and Cardiac Tamponade
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
   2. Superior Vena Cava Syndrome
      1. Pathophysiology
      2. Clinical Presentation and Diagnosis
      3. Treatment
5. Pulmonary Emergencies
   1. Acute Airway Obstruction
      1. Clinical Presentation and Diagnosis
      2. Treatment
   2. Acute Airway Hemorrhage
      1. Clinical Presentation and Diagnosis
      2. Treatment
6. Infectious Emergencies
   1. Febrile Neutropenia
      1. Pathophysiology
      2. Microbiology
      3. Clinical Presentation and Diagnosis
      4. Treatment
   2. Fever in Patients Without a Functional Spleen
7. Unique Emergencies Related to Systemic Tumor-Directed Therapy
8. Conclusion
9. References